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KMID : 0981820080280030244
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Korean Journal of Laboratory Medicine
2008 Volume.28 No. 3 p.244 ~ p.250
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Metabolic Characteristics and Associated Factors of Nonalcoholic Fatty Liver Disease Diagnosed at Medical Checkups
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Nah Eun-Hee
Park Jae-Young
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Abstract
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Background: Nonalcoholic fatty liver disease (NAFLD) has been reported to be related with metabolic disorder and frequently accompanied by abnormal liver function. This study was performed to investigate the metabolic characteristics of NAFLD and its associated factors.
Methods: We analysed 7,150 subjects diagnosed with NAFLD (n=2,381) or normal liver (n=4,769) and classified them into four groups based on ultrasonography and ALT levels as follows: 1) Control (normal liver and ALT), 2) increased ALT (normal liver with increased ALT), 3) NAFLD I (fatty liver with normal ALT), and 4) NAFLD II (fatty liver with increased ALT). Age, blood pressure, body mass index (BMI), fasting glucose, blood lipids, and high sensitivity C-reactive protein (hsCRP) were compared, and the incidence of metabolic syndrome was also determined in each group.
Results: The diastolic blood pressure, BMI, fasting glucose, total cholesterol, triglyceride, hsCRP, and the incidence of metabolic syndrome, were the highest in the NAFLD II group, followed by the NAFLD I group, the increased ALT group, and the control group in descending order. Meanwhile, HDL cholesterol (HDL-C) was the lowest in the NAFLD II group. Male sex, age, systolic blood pressure, BMI, fasting glucose, triglyceride, LDL cholesterol (LDL-C), and hsCRP were associated with NAFLD (P<0.001). An increased level of ALT in NAFLD was significantly related with male sex,
increased BMI, fasting glucose, triglyceride, and LDL-C, younger age and decreased HDL-C (P<0.001).
Conclusions: NAFLD was related with metabolic syndrome and the risk factors of cardiovascular disease in Koreans. The correlation was more prominent in NAFLD with increased ALT. Thus, a more intensive management is required for the individuals in the NAFLD with increased ALT.
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KEYWORD
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Nonalcoholic fatty liver disease, ALT, Cardiovascular risk factors, Metabolic syndrome
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